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This increase in oxidative stress was not seen in chronic smokers and chronic vapers, likely because they already have a higher level of oxidative stress from long-term exposure, Middlekauff said

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Table 1: Examples of high-dose, long-term oral prednisolone treatments Excessive dosage or prolonged use of GC may potentiate their normal physiological effects, resulting in mineralocorticoid and glucocorticoid-related side effects (see Table 2) 15,16

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